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Published on:July 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(3):400-413
Review Article | doi:10.5530/ijper.53.3.73

Potential of Pure Phytoconstituents and Herbs in Protection of Drug Induced Nephrotoxicity

Authors and affiliation (s):

Areeba Insaf, Pratap Nath Raju*

Department of Pharmacognosy, Delhi Pharmaceuitical Sciences and Research University, Mehrauli-Badarpur Rd, Sector-3, Pushp Vihar, New Delhi, INDIA.


Global trend is setting towards improved ‘quality of life’, for that there is considerable evidence of an increase in demand for medicinal plants. According to the WHO report, between 65% and 80% of the populations of developing countries use medicinal plants as remedy nowadays. Kidney is one of the vital organs of body and Nephrotoxicity is one of the most common problems and it occurs as a result when body is exposed to a drug or toxin. This review article aims to report and to introduce the effect of most important medicinal herbs, herbal formulations and some of the specific phytoconstituents that are used to prevent and treat anticancer, aminoglycoside, non-steroidal anti-inflammatory and few other classes of drug-induced nephrotoxicity. Particularly anti-cancer drugs among all other classes of drugs, cause high toxicity leading kidney damage and irreparable kidney injury. So, attention has recently been paid to seek out alternatives such as natural drugs that are effective and also less toxic. According to the studies carried out on different animals and cell line, many medicinal plants, herbal formulations and a few plant-based constituents by their antioxidant, free-radical and anti-inflammatory properties are found to be helpful in preventing drug-induced nephrotoxicity.

Key words: Nephrotoxicity, Cisplatin, Gentamicin, Natural compounds, Medicinal plants.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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