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Indian Journal of Pharmaceutical Education and Research, 2019; ():xx-xx
Original Article | doi:

Preparation and in vitro and in vivo Evaluation of Chitosan- Gliclazide Mucoadhesive Microparticles by an Emulsification- Desolvation- Crosslinking Technique


Authors and affiliation (s):

P. Veera Lakshmi1, K.P.R Chowdary2,*, A. Prameela Rani3, S.V.U.M. Prasad1

1School of Pharmacy, JNTUK College in Kakinada, Andhra Pradesh, INDIA.

2Vikas Institute of Pharmaceutical Sciences, Rajahmundry, Andhra Pradesh, INDIA.

3University College of Pharmaceutical Sciences, Acharya Nagarjuna University (ANU), Guntur, Andhra Pradesh, INDIA.

Abstract:

Introduction: Recently much emphasis is being laid on the development of microparticles because of their potential benefits such as increased bioavailability, reduced risk of systemic toxicity, reduced risk of local irritation and predictable gastric emptying. Objective: The objective of the present study is to prepare and evaluate mucoadhesive microparticles of chitosan-gliclazide for oral controlled release. Methods: A new method namely emulsification-desolvation-crosslinking was used for the preparation of chitosangliclazide microparticles and the microparticles were evaluated by in vitro and in vivo methods. Results: Spherical chitosan-gliclazide microparticles could be prepared by the emulsification-desolvation-crosslinking method. The method was reproducible with regard to size and size distribution of the microparticles. The chitosan-gliclazide microparticles exhibited good muoadhesive property. Gliclazide release from the chitosan microparticles was slow and extended over longer periods of time and depended on the proportion of core: coat. Gliclazide release from the chitosan microparticles was by diffusion mechanism. Microparticles (F3) prepared using a core: coat ratio of 8:2 gave slow and controlled release of gliclazide over 12 h similar to that of commercial gliclazide SR tablets. In the in vivo evaluation, the gliclazide microparticles (F3) gave a slower reduction in serum glucose levels and the reduced glucose levels were sustained over longer periods of time. Conclusion: Microparticles (F3) are considered as a promising microparticulate drug delivery system for oral controlled release of gliclazide over 12 h for b.i.d administration.

Key words: Mucoadhesive microparticles, Chitosan, Gliclazide, Emulsification-desolvationcrosslinking method, Oral controlled release.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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