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Published on:September 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4):663-669
Original Article | doi:10.5530/ijper.53.4.128

Preparation and in vitro and in vivo Evaluation of Chitosan-Gliclazide Mucoadhesive Microparticles by an Emulsification- Desolvation- Crosslinking Technique

Authors and affiliation (s):

Pabbiniddi Veera Lakshmi1, Kora Pattabhi Rama Chowdary2,*, Avula Prameela Rani3, Sahini Venkata Uma Maheswara Prasad1

1School of Pharmacy, JNTUK College, Kakinada, Andhra Pradesh, INDIA.

2Vikas Institute of Pharmaceutical Sciences, Rajahmundry, Andhra Pradesh, INDIA.

3University College of Pharmaceutical Sciences, Acharya Nagarjuna University (ANU), Guntur, Andhra Pradesh, INDIA.


Introduction: Recently much emphasis is being laid on the development of microparticles because of their potential benefits such as increased bioavailability, reduced risk of systemic toxicity, reduced risk of local irritation and predictable gastric emptying. Objective: The objective of the present study is to prepare and evaluate mucoadhesive microparticles of chitosan-gliclazide for oral controlled release. Methods: A new method namely emulsification-desolvation-crosslinking was used for the preparation of chitosangliclazide microparticles and the microparticles were evaluated by in vitro and in vivo methods. Results: Spherical chitosan-gliclazide microparticles could be prepared by the emulsification-desolvation-crosslinking method. The method was reproducible with regard to size and size distribution of the microparticles. The chitosan-gliclazide microparticles exhibited good muoadhesive property. Gliclazide release from the chitosan microparticles was slow and extended over longer periods of time and depended on the proportion of core: coat. Gliclazide release from the chitosan microparticles was by diffusion mechanism. Microparticles (F3) prepared using a core: coat ratio of 8:2 gave slow and controlled release of gliclazide over 12 h similar to that of commercial gliclazide SR tablets. In the in vivo evaluation, the gliclazide microparticles (F3) gave a slower reduction in serum glucose levels and the reduced glucose levels were sustained over longer periods of time. Conclusion: Microparticles (F3) are considered as a promising microparticulate drug delivery system for oral controlled release of gliclazide over 12 h for b.i.d administration.

Key words: Mucoadhesive microparticles, Chitosan, Gliclazide, Emulsification-desolvationcrosslinking method, Oral controlled release.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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