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Published on:September 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4):654-662
Original Article | doi:10.5530/ijper.53.4.127

Formulation and Characterization of pH Induced in situ Gels Containing Sulfacetamide Sodium for Ocular Drug Delivery: A Combination of Carbopol®/ HPMC Polymer

Authors and affiliation (s):

Ravi Sheshala1,2,*, Ng Jun Ming1, Yong Yee Kok1, Thakur Raghu Raj Singh3, Kamal Dua4,5

1School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, MALAYSIA.

2Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300 Bandar Puncak Alam, Kuala Selangor, MALAYSIA.

3School of Pharmacy, Queen’s University Belfast, Belfast, BT9 7BL, UNITED KINGDOM.

4Discipline of Pharmacy, Graduate School of Health, University Technology Sydney, Ultimo, New South Wales, AUSTRALIA.

5Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) and School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, AUSTRALIA.


Introduction: Topical delivery of eye drops which currently accounts to 90% of available ocular dosage forms are ideal for the treatment of eye diseases but having limitations of poor therapeutic response and low bioavailability. Objectives: The objectives of present research was to develop and characterize sustained release in situ ocular gels containing sufacetamide sodium using pH induced gelling polymers for improved therapeutic response and patient compliance. Methods: In situ gel formulations prepared by dispersion method using Carbopol® 940/Carbopol® 934 alone or in combination with hydroxypropyl methylcellulose (HPMC E4M). Formultaions were evaluated for appearance, pH, viscosity, gelling capacity, drug content and in vitro drug release. The optimized formulation was assessed for sterility and antimicrobial efficacy using disk diffusion technique in comparison to commercial eye drops (Albucid®10%). Results: The appearance of in situ gels were clear and free flowing in nature however, a viscous clear solution with no flow was produced for formulations consisting of 0.8% w/v Carbopol® 940/Carbopol® 934 and 2% w/v HPMC E4M. pH of all the formulations was within the range of 5.9 to 6.7. In situ gels with Carbopol® 940 demonstrated higher viscosity compared to Carbopol® 934 and drug release was sustained over a period of 8 h. The selected formulation containing 0.8% w/v Carbopol® 940 and 1.5% w/v HPMC E4M passed sterility test and demonstrated similar antimicrobial efficiency compared to commercial product. Conclusion: Carbopol®/HPMC-based in situ gels have potential to improve patient’s compliance by reducing the dosing frequency and could be a viable alternative to commercial product.

Key words: In situ gel, Ocular, Sulfacetamide sodium, Carbopol®/HPMC, in-vitro release, Antimicrobial efficacy.



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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).


Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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