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Published on:September 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4):577-594
Review Article | doi:10.5530/ijper.53.4.119

Skin Targeting Approaches in Cosmetics

Authors and affiliation (s):

Swarnlata Saraf*, Chanchal Deep Kaur, Anshita Gupta, Nikita Verma

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, INDIA.


Objective: To emphasize and summarize the main component of skin and approaches to target them. Methods: Skin targeting approaches in cosmetics is a review of all the relevant papers known to the author was conducted. Results: The exhaustive review on the basis of the previously reported paper revealed that the skin is a complicated and intact structure having vast of targeting component such as Keratin, Elastin fibres, ECM, MMPs, collagen, Hyaluronic Acid etc and apart from that the receptor and signalling pathway mediated skin targeting is also a promising approach to deliver bioactive at specific site of skin by the help of Surface engineered nanocarriers. Receptors like Epidermal Growth Factor Receptor (EGFr), interleukin-1 receptor (IL-1r), Tumor Necrosis Factor Receptor (TNFr), Platelet-Derived Growth Factor Receptor (PDGFr) and Platelet- Activating Factor Receptor (PAF-r) are the types of receptor present in skin cells. These receptors are targeted by nanocarriers which are surface engineered by conjugating them ligands which show the specific affinity towards receptor present in the skin cells.

Key words: Skin, Targeting, ECM, MMPs, Collagen, EGFr, IL-1r, TNFr, PDGFr, PAF-r, Nanocarriers.



Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).


Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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