Home | Articles
Published on:September 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4):723-731
Original Article | doi:10.5530/ijper.53.4.137

Formulation Development and Evaluation of Gastro Retentive Bio Adhesive Drug Delivery System for Moxifloxacin. HCl


Authors and affiliation (s):

Raghavendra Kumar Gunda1,*, Arumugam Vijayalakshmi2

1School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, INDIA.

2Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, INDIA.

Abstract:

Objective: The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various drug release modifiers. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Methods: SR granules were prepared by gastro retentive tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK100M, Lannea coromandelica gum (LCG) by moist granulation technique. Totally 10 SR granule formulations were prepared and subjected to precompression analysis and drug release profiles. Based on the results screening of concentrations for polymers and are used for Tablet formulations. Six tablet formulations were designed and are evaluated for various pharmacopoeial tests. Drug release profiles of formulation trails subjected to kinetic modeling. a,b,r were determined. Results: The results reveals that retention time decreases with decreased viscosity of polymer. F16 prepared with LCG was found to have highest swelling property. High bioadhesive strength of the formulation is likely to increase its GI residence time. Lannea coromandelica gum powder needs to explored as a sustain release material at commercial scale.

Key words: Moxifloxacin. HCl, Gastroretentive, Bio adhesion, HPMCK100M, Lannea coromandelica gum, Swelling Study.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
4 + 1 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.




 

Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

User login

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
2 + 1 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs