Home | Articles
Published on:Jul 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(3):253-258
Original Article | doi:NILL

Novel Approach in Designing Mouth Dissolving Tablets of Cetirizine Hydrochloride


Authors and affiliation (s):

Venu Priya R, Sunitha Rani S, Rajesh Pavan A, Naresh G and Hindustan Abdul Ahad

Department of Pharmaceutics, Balaji College of Pharmacy, Anantapur- 515001, Andhra Pradesh, India

Abstract:

The present work was to design and evaluation of mouth dissolving tablets of Cetirizine hydrochloride by using superdisintegrants. A novel approach has been made to develop Cetirizine hydrochloride mouth dissolving tablets by including clove oil as flavor and local anesthetic on taste buds. The drug and excipients were characterized using Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FTIR) techniques. The drug excipient blend was evaluated for examined physicochemical properties. The prepared tablets were evaluated for thickness, hardness, friability, mouth feel, wetting time, content uniformity, in vitro disintegration time, in vivo disintegration time and in vitro dissolution studies. Formulation (F-4) showed quick disintegrating time of 228.26 s, which is very characteristic of mouth dissolving tablets. Further optimized formulations (F-4 and F-5) were subjected to accelerated stability studies for 3 months at temperature 40±5ºC/75±5%RH. The tested tablets did not show any changes with respect to taste, disintegration and dissolution profiles. In conclusion, the results of this work suggest the inclusion of Clove oil (which has both flavoring and local anesthetic actions), which reduces the processing charges and use of costlier taste masking agents.

Keywords: Mouth dissolving tablet, Cetirizine hydrochloride, Clove oil, superdisintegrants.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
15 + 4 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.




 

User login

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
15 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs