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Published on:November 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4s):s466-s474
Review Article | doi:10.5530/ijper.53.4s.140

A Review on Complications Confronted with Skin Penetration and Assessment of Topical Formulations in Dermal Drug Development


Authors and affiliation (s):

Kalikrishna Praveen Gadde1, Angel Treasa Alex2, Alex Joesph1,*

1Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, INDIA.

2Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, INDIA.

Abstract:

A topical drug-delivery system is the most accepted drug delivery system. One of the pre-requisites for a topical formulation is its ability to penetrate the skin membrane to elicit the intended action. Many in vitro skin permeation studies are reported by scientists to evaluate the penetration of the drug into human skin. Several direct methods including tape stripping, in vitro percutaneous studies measures skin tissue concentration. While indirect methods like plasma collection, micro-dialysis etc. the information produced is translated and transformed to offer details of skin tissue concentration. The present review focuses on various techniques in use for the estimation of topical drugs to assess skin permeation, along with their merits and demerits and challenges encountered in them. Additionally, this review also focus on limitations in topical drug development.

Key words: Skin permeation, Microdialyis, in vitro Percutaneous Studies, Tape stripping, Skin contamination.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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