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Published on:November 2019
Indian Journal of Pharmaceutical Education and Research, 2019; 53(4s):s666-s677
Original Article | doi:10.5530/ijper.53.4s.163

Complimentary Effects of Curcumin for Enhancing Efficacy of Acetylsalicylic Acid against Prostate Cancer


Authors and affiliation (s):

Tapas Kumar Mohapatra1, Debasish Mohapatra2, Bharat Bhusan Subudhi1,*

1Drug Development and Analysis Laboratory, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, INDIA.

2Tumor Microenvironment and Animal Models Laboratory, Department of Translational Research, Institute of Life Sciences, Bhubaneswar, Odisha, INDIA.

Abstract:

Background: Prostate cancer is the 6th leading cause of cancer death worldwide. Androgen Deprivation Therapy (ADT) in prostate cancer enhances the risk of Rheumatoid Arthritis (RA). Acetylsalicylic Acid (ASA) can be potentially repurposed against prostate cancer and arthritis. However, its efficacy is low and use is associated with nephrotoxicity as well as gastrotoxicity. Curcumin with reported ability to potentiate anti-inflammatory effects and reduce oxidative stress, can be used as a complementary therapy to enhance efficacy of ASA against prostate cancer and arthritis. This can also minimise ASA induced nephrotoxicity and gastrotoxicity. Aim and Objectives: To evaluate the ability of curcumin to enhance efficacy of ASA against prostate cancer, arthritis while minimising its adverse effects. Methods: In-vitro anticancer activity was assessed in DU-145 (Androgen-independent) and LNCaP (Androgen-dependent) cells. Effect against arthritis was evaluated in complete Freund’s adjuvant (CFA) induced arthritis model in rats. Biochemical factors, radiology and histopathology were examined. Protection against kidney dysfunction and ulceration was determined. Results: Curcumin on co-administration with ASA (ASA+Cur) (25 μM + 25 μM) showed higher efficacy against DU-145 and LNCaP cell model. This co-use showed significant (p<0.001) inhibition of arthritis index (AI). The erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF) were significantly (p<0.001) decreased from their elevated level. It also reduced tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β) and interleukin 6 (IL-6) at the molecular level. While it showed moderate gastro-protection, there was no adverse effect on kidney functions. Conclusion: Curcumin seems to enhance the effect of ASA against androgen dependent as well as androgen independent prostate cancer while reducing arthritis. Simultaneously, it reduces ASA induced gastrotoxicity and prevents nephrotoxicity.

Key words: Acetylsalicylic acid, Androgen deprivation, Prostate cancer, Arthritis index, Gastric ulcer.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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