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Published on:December 2019
Indian Journal of Pharmaceutical Education and Research, 2020; 54(1):55-67
Original Article | doi:10.5530/ijper.54.1.7

Formulation and Evaluation of Cefixime Nanosuspension for the Enhancement of Oral Bioavailability by Solvent-Antisolvent Method and its Suitable Method Development


Authors and affiliation (s):

Vinayak Shivamurthi Mastiholimath1, Bhagat Ankita Rajendra1,*, Vinodkumar Shirshalappa Mannur1, Panchaxari Mallappa Dandagi2, Anand Panchaxari Gadad2, Pukar Khanal3

1Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research (KAHER) Belagavi, Karnataka, INDIA.

2Department of Pharmaceutics, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research (KAHER) Belagavi, Karnataka, INDIA.

3Department of Pharmacology and Toxicology, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research (KAHER) Belagavi, Karnataka, INDIA.

Abstract:

Aim: The objective of the present study was to develop and evaluate cefixime nanosuspension to enhance its oral bioavailability. Materials and Methods: The method used was solvent/ antisolvent method in which methanol and Millipore water was used as solvent and antisolvent respectively. The surfactants used for the preparation were PVP K30 and HPMC K100 which was found to be compatible in the formulation. Compatibility of the drug and drug with its excipients was found out by FTIR studies. Characterization of the optimized Cefixime Nanosuspension was carried out by particle size analysis, Differential Scanning Calorimetry, Zeta Potential, Drug content, in-vitro drug release studies, Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy(TEM). The antimicrobial activity of cefixime nanosuspension was done by Disk diffusion method against E. coli performed in nutrient agar with different concentrations of the formulation. The Minimum Inhibitory Concentration (MIC) was determined by calculating Zone of inhibition. A method was developed forcefixime nanosuspension and validated by High Performance Thin Layer Chromatography (HPTLC). Results: The optimizedcefixime nanosuspension was validated for Identification, Linearity, Specificity, Precision and Recovery. The Recovery of cefixime nanosuspension was found to be 95.57%.

Key words: Cefixime nanosuspension, Method development, HPTLC, Solvent/ Antisolvent method, Validation.

 

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IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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