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Published on:Apr 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(2):105-111
Original Article | doi:NILL

Enhanced Iontophoretic Permeation of Rizatriptan Benzoate from Thermoreversible Gel Based System: Effect of Penetration Enhancers and Pulsed Current


Authors and affiliation (s):

S.R. Lahoti*1, N.G Taur1, A.R. Khan1 and P.K. Puranik2

1Department of Pharmaceutics, Y. B. Chavan College of Pharmacy, Aurangabad, (MS) India.

2Government College of Pharmacy, Aurangabad, Maharashtra, India.

Abstract:

The purpose of present research work was to enhance the iontophoretic delivery of Rizatriptan Benzoate (RZB) through optimized gel based formulation by using chemical penetration enhancers and to study the effect of pulsed current on permeation through guinea pig, Wistar rat and human cadaver skin. Modified Franz diffusion cell was used to study the in vitro permeation across various types of skin by iontophoresis. The thermo-reversible gel was prepared and optimized by cold method using poloxamer 407 as a gelling agent. Thermo-reversible gel with 20% w/v poloxamer 407 has suitable gelation temperature and viscosity for iontophoretic delivery of RZB. The highest permeation obtained was with iontophoresis in combination with 10% v/v PEG-400 as penetration enhancer. The permeation of RZB was significantly higher with pulsed current (1:1 as a ON: OFF ratio) at 0.5 mA/cm2 as a current density than direct continuous current. It was observed that highest permeation was obtained through the rat skin as compared to guinea pig skin, and the permeation through human epidermis was lowest. The study reveals that it is feasible to deliver RZB by iontophoresis in combination with penetration enhancer and pulsed current from Poloxamer thermo-reversible gel.

Keywords: Transdermal, poloxamer, Iontophoresis, Rizatriptan

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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