Development and Optimization of Capecitabine loaded Nanoliposomal System for Cancer Delivery

Abstract:

Objectives: The Main objective of this study was to develop and optimize Capecitabine loaded nanoliposomes for prolonged drug delivery in cancer treatment. Methods: Liposomes were prepared by the thin film hydration method followed by sonication. The parameters affecting the vesicle size and percentage drug entrapment of liposome are amount of soyaphosphatidyl choline and cholesterol used in their preparation. The Capecitabine liposomal formulation was optimized using 3² factorial design in this amount of soya Phosphatidylcholine and cholesterol were selected as two independent variables to obtain stable liposome with small vesicle size and maximum entrapment efficiency. Results: Compatibility studies were carried out by using FT-IR and DSC, the results showed that there was no significant interaction between drug and excipients. The formulated liposomal prepartions were evaluated for various parameters and results were obtained for optimized batch (B3) Showed vesicle size 178.9nm, zeta potential -77.9mV to -82.7mV, entrapment efficiency 79.65% and percentage drug release 92.07% up to 12 h. Conclusion: Liposomal drug delivery is targeted as to provide more drug concentration at the site of action and with a sustainable drug release followed Higuchi-matrix model. Ultimately, reducing the dosing frequency with minimizing the side effects related to high drug intake. Liposome has been provided a spectrum of options and opportunities for designing and practicing site specific, targeted drug therapy.

Key words: Capecitabine, Liposome, 3² Factorial design, Percent drug entrapment, Release kinetics.