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Published on:March 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(2):376-384
Original Article | doi:10.5530/ijper.54.2.43

Development and Optimization of Capecitabine loaded Nanoliposomal System for Cancer Delivery


Authors and affiliation (s):

Sandip Mohan Honmane1, Sagar Maruti Chimane2, Sandip Akaram Bandgar2,*, Shitalkumar Shivagonda Patil2

1Department of Pharmaceutics, Annasaheb Dange College of B. Pharmacy, Ashta, Shivaji University, Kolhapur, Maharashtra, INDIA.

2Department of Pharmaceutics, Ashokrao Mane College of Pharmacy, Peth-Vadgaon, Shivaji University, Kolhapur, Maharashtra, INDIA.

Abstract:

Objectives: The Main objective of this study was to develop and optimize Capecitabine loaded nanoliposomes for prolonged drug delivery in cancer treatment. Methods: Liposomes were prepared by the thin film hydration method followed by sonication. The parameters affecting the vesicle size and percentage drug entrapment of liposome are amount of soyaphosphatidyl choline and cholesterol used in their preparation. The Capecitabine liposomal formulation was optimized using 32 factorial design in this amount of soya Phosphatidylcholine and cholesterol were selected as two independent variables to obtain stable liposome with small vesicle size and maximum entrapment efficiency. Results: Compatibility studies were carried out by using FT-IR and DSC, the results showed that there was no significant interaction between drug and excipients. The formulated liposomal prepartions were evaluated for various parameters and results were obtained for optimized batch (B3) Showed vesicle size 178.9nm, zeta potential -77.9mV to -82.7mV, entrapment efficiency 79.65% and percentage drug release 92.07% up to 12 h. Conclusion: Liposomal drug delivery is targeted as to provide more drug concentration at the site of action and with a sustainable drug release followed Higuchi-matrix model. Ultimately, reducing the dosing frequency with minimizing the side effects related to high drug intake. Liposome has been provided a spectrum of options and opportunities for designing and practicing site specific, targeted drug therapy.

Key words: Capecitabine, Liposome, 32 Factorial design, Percent drug entrapment, Release kinetics.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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