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Published on:May 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(2s):s12-s18
Review Article | doi:10.5530/ijper.54.2s.57

Modified Pectins for Colon-Specific Drug Delivery


Authors and affiliation (s):

Aneesh Muvva, Indhu Annie Chacko, Vivek Ghate, Shaila Angela Lewis*

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, INDIA.

Abstract:

Treatment of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome and colonic cancer by targeting drug to the colon is a viable approach. Due to gastric degradation of drugs, proteins and peptides, only minimum amount of drug gets absorbed when administered orally and shows little therapeutic activity. Hence the strategy of delivering drugs to colon known as colon targeted drug delivery evolved. Pectin a naturally occurring biodegradable polysaccharide has gained importance as a carrier for colon-specific delivery attributed to swelling nature as well as the ability to resist gastric degradation. This review describes the chemistry of pectin, mechanism of action and various novel modified pectin formulations aimed at targeting the colon.

Key words: Colon targeting, Intestinal microflora, Modified pectin forms, Gelling property, biodegradable polysaccharide, Drug delivery.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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