Home | Articles
Published on:May 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(2s):s173-s181
Original Article | doi:10.5530/ijper.54.2s.73

Isoxsuprine Hydrochloride Loaded Cellulose Acetate Phthalate Microsponge Drug Delivery System: Design and Evaluation


Authors and affiliation (s):

Shubhangi Kagade1,*, Jignasa Savjani2, Dattatraya Yadav2, Prashant Gurav3

1Department of Pharmaceutics, SVERI’s College of Pharmacy, Pandharpur, Maharashtra, INDIA.

2Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, INDIA.

3Department of Pharmaceutics, Indira Institute of Pharmacy, Sadavali, Ratnagiri, Maharashtra, INDIA.

Abstract:

Aim: The present study was aimed to Design and evaluation of microsponge based drug delivery system of Isoxsuprine Hydrochloride. The microsponge drug delivery system is designed for site specific and controlled release of drug by using cellulose acetate phthalate to improve the site-specific absorption of drug. Materials and Methods: The microsponges was formulated by modified quasi emulsion solvent diffusion technique. The chemical interaction between Isoxsuprine Hydrochloride, cellulose acetate phthalate, ethyl cellulose and polyvinyl pyrrolidone was studied by FTIR, the results of FTIR it was confirmed that there were no chemical reaction in between drug and polymer. The compatibility study of drug and polymer were confirmed by DSC. Results: The results of FTIR it was confirmed that there were no chemical reaction in between drug and polymer. The in vitro drug release found in between range of 91.97% to 98.78% the highest % CDR was shown by formulation MS5. The optimized formulation (MS5) demonstrated favorable % entrapment efficiency (93.6%), % buoyancy (78%) and % cumulative drug release (98.78%). SEM revealed the release of Isoxsuprine Hydrochloride in controlled release pattern from spherical and porous microsponges. Conclusion: This study provides a new approach to formulate and evaluate the microsponges of Isoxsuprine Hydrochloride for treatment of premature labor during pregnancy.

Key words: Microsponges, Isoxsuprine Hydrochloride, Cellulose acetate phthalate, Quasi emulsion solvent diffusion, Site specific absorption.

 




 

Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

User login

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs