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Published on:May 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(2s):s1-s11
Review Article | doi:10.5530/ijper.54.2s.56

Supercritical Fluid Technology and its Pharmaceutical Applications: A Revisit with Two Decades of Progress

Authors and affiliation (s):

Liew Kai Bin1,*, Ashok Kumar Janakiraman2, Fashli Syafiq Abd Razak1, A.B.M. Helal Uddin3, Md Zaidul Islam Sarker3, Long Chiau Ming4,5, Bey Hing Goh6,7

1Faculty of Pharmacy, University of Cyberjaya, Cyberjaya, Selangor, MALAYSIA.

2Faculty of Pharmaceutical Sciences, UCSI University, Cheras, Kuala Lumpur, MALAYSIA.

3Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, MALAYSIA.

4PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, BRUNEI DARUSSALAM.

5Pharmacy, School of Medicine, University of Tasmania, Hobart, TAS, AUSTRALIA.

6School of Pharmacy, Monash University Malaysia, Sunway, Selangor, MALAYSIA.

7School of Pharmacy, Zhejiang University, Hangzhou, PEOPLE REPUBLIC OF CHINA.


Over the past two decades, supercritical fluid technology has emerged as one of the most important technologies applied in many fields such as cosmetic, food and pharmaceutical. Supercritical fluid extraction process offers numerous advantages such as easy, effective, inexpensive, high quality of solute extraction and environmentally friendly. This mini-review describes the fundamentals of supercritical fluid technology, the function of supercritical fluid as solvent and anti-solvent, mechanism of supercritical fluid, advantages and disadvantages and revisit the application of supercritical fluid technology in pharmaceutical sciences. In-depth discussion with recent examples of extraction of natural products, particle design in drug delivery, preparation on pharmaceutical powder, drug solubilization, inclusion complex, polymer impregnation, liposomal formulations, purification and polymorphism as well as drug extraction analysis are also presented. Key aspects and processing considerations of supercritical fluid technologies are reviewed to assist scientists to generate other related experimental works.

Key words: Bioavailability enhancement, Biomedical applications, Drug delivery, Polymeric carriers, Supercritical fluids.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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