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Published on:May 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(2s):s269-s276
Original Article | doi:10.5530/ijper.54.2s.83

Antifungal Nail Lacquer Loaded with Extract of Cissus quadrangularis for Treatment of Onychomycosis


Authors and affiliation (s):

Ashlesha Pravin Pandit1,*, Amarnath Arunrao Kedar1, Suvidya Vilas Ranaware1, Kishanchandra Radheshyam Khandelwal2

1Department of Pharmaceutics, JSPM’s Rajarshi Shahu College of Pharmacy and Research, Tathwade, Pune, Maharashtra, INDIA.

2Department of Pharmacognosy, JSPM’s Rajarshi Shahu College of Pharmacy and Research, Tathwade, Pune, Maharashtra, INDIA.

Abstract:

Objectives: An attempt was made to prepare transparent nail lacquer containing natural antifungal agent obtained from extract of whole plant of Cissus quadrangularis for the treatment of onychomycosis. Methods: The extract of C. quadrangularis was evaluated for antifungal study against Candida albicans. Minimum inhibitory concentration of extract against C. albicans was performed to get the amount of extract to be loaded in the nail lacquer. Extract was further evaluated for phytochemical study such as test for steroids, glycoside and flavonoids. Nail lacquer was prepared by using nitrocellulose, ethyl cellulose, ethyl acetate, salicylic acid, dibutyl phthalate, extract of C. quadrangularis and acetone with continuous stirring. The nail lacquer of fluconazole was prepared and compared with formulation. Formulations of nail lacquer were evaluated for drying time, gloss, nonvolatile content, water resistance, viscosity, smoothness of flow. In-vitro transungual permeation study was performed through goat nail. Results: Phytoconstituents such as flavonoid and quinine were found present in the extract. Antifungal activity of nail lacquer and fluconazole formulation against C. albicans was found good (zone of inhibition of 20±2mm at 50mg/ml, 16±1mm for 40mg/ml respectively). Drying time of formulation was 62-70 s with visually seen glossiness of formulation. Formulation of nail lacquer showed good non-volatile content, water resistance and viscosity with smoothness of flow. In-vitro permeation of F7 formulation showed 90.9% of permeation which was faster within 24 hr. Conclusion: Thus, C. quadrangularis extract loaded antifungal nail lacquer could be a good choice for treatment of onchomycosis rather than fluconazole.

Key words: Onychomycosis, Cissus quadrangularis, Transungual, Nail lacquer, Antifungal.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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