Lipid Nanocarriers: Promising Approach for Oral Drug Delivery System

Abstract:

Background: A suitable drug delivery system has been work on the strategy to enable safe and effective therapeutic efficacy. Drug discovery program, it has huge number of drug molecules are lipophilic as poor aqueous soluble. Oral drug delivery system is a safe, convenient and easy route for drug administration. Bioavailability is a major issue. Drug administrated with low bioavailability may lead to an ineffective therapeutic efficacy and several adverse effects. However, there are several reasons which may be responsible for poor bioavailability such as constraints of aqueous solubility, poor dissolution rate and permeability, hepatic first-pass metabolism and efflux. These hindrances are the massive challenges of poorly aqueous soluble drugs. Although, conventional approaches have troubles to succeed efficacious therapeutic efficacy of drug. Materials and Methods: Lipid nanocarriers have been promising and attractive approach and widely used in formulation development to improve the therapeutic efficacy of drugs. These nanocarriers have made the drug in pre-dissolved form with high durability Results: Lipid nanocarriers are more biodegradable, safe and bio-friendly with the biological system. Lipid nanocarriers have potentially overcome such hindrances thus improve the therapeutic efficacy to the drugs. Recently, lipid nanocarriers including it generations have widely preferred in formulation development due to its high durability and uniformity. Conclusion: Therefore, lipid nanocarriers have been considered as safe, prominent and robust strategy for improving the therapeutic efficacy of poorly aqueous soluble drugs.

Key words: Lymphatic system, Liposome, Solid lipid nanoparticle, Self-nanoemulsifying, Nanostructural lipid carrier.