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Published on:May 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(2s):s67-s74
Review Article | doi:10.5530/ijper.54.2s.62

Apple Cider Vinegar (ACV) and their Pharmacological Approach towards Alzheimer’s Disease (AD): A Review

Authors and affiliation (s):

Smriti Tripathi, Papiya Mitra Mazumder*

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology-Mesra, Ranchi, Jharkhand, INDIA.


Alzheimer's disease (AD) is a neurological degenerative condition described by a progressive decline in memory and associated with dementia. This disease arises usually after 65 years in individuals. Oxidative stress is the major cause of dementia connected with Alzheimer's disease. Here there is an imbalance between the creation and clearance of amyloid β protein, which leads to accumulation of amyloid β plaque in the brain and produces neuronal cell death. Anti-Alzheimer's medications help to cover the symptoms of disease but do not cure the cause of disease. Confirmatory studies suggest that a healthy diet of fruits and green vegetables containing phenolic combinations may reduce the risk of Alzheimer's disease (AD). Apple cider vinegar (ACV) contains phenolic compounds like catechin, caffeic acid, gallic acid, chlorogenic acids and p-coumaric acid having high antioxidant potential. Phenolic compounds are not essential for survival but it can protect against various chronic diseases. Various researches showed that phenolic compounds cure β amyloid and tau protein correlated problems associated with AD. Regular consumption of these healthy substances in the diet may prevent the neuronal cells from oxidative stress which leads to AD. The purpose of this review is to highlight the health benefit role, functional property and therapeutic uses of Apple Cider Vinegar.

Key words: Apple Cider Vinegar, Alzheimer’s disease, Oxidative stress, Phenolic compounds, Aβ aggregation, Pharmacological activities



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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