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Published on:Apr 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(2):185-191
Original Article | doi:NILL

Synthesis, Characterisation and Anti-inflammatory Activity of some Novel Quinazolin-4-(3h)-one Analogues


Authors and affiliation (s):

N.K. Sathish1*, S Shahensha2, M Irfan Ali1 and I.A. Chethan1

1Department of Pharmaceutical Chemistry, SAC College of Pharmacy, BG Nagara Mandya-571448, Karnataka, India.

2Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, KM Doddi, Mandya.

Abstract:

Some new 2-[(E)-2-(substituted phenyl) ethenyl]-3-(2/4methyl phenyl) quinazolin-4(3H)-ones (Q1a-f Q2a-f ) have been synthesized from 3-(2- a-f, a-f methyl phenyl) quinazolin-4(3H)-one (Q1) and 3-(4-methyl phenyl) quinazolin-4(3H)-one (Q2) by introducing different aromatic aldehydes. The synthesized compounds have been characterized by IR, 1H NMR, 13C NMR and Mass spectral techniques and screened for anti-inflammatory activity by using carrageenan induced rat paw edema method. Compounds Q1a, Q1e, Q1f and Q2f showed potent activity when compared to diclofenac sodium as standard. Examination of the relationship between lipophilicity and anti-inflammatory activity of quinazolines showed poor correlation.

Keywords: Quinazoline, Anti-inflammatory activity, Lipophilicity, Diclofenac sodium

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