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Published on:August 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(3):637-646
Original Article | doi:10.5530/ijper.54.3.113

Mupirocin Mounted Copper Nanoparticle Offered Augmented Drug Delivery against Resistant Bacteria


Authors and affiliation (s):

Vikram Verma1, Dinesh Kaushik2*

1Student, Department of Pharmaceutics, Hindu College of Pharmacy, Sonipat, Haryana, INDIA.

2Associate Professor, Department of Pharmaceutics, Hindu College of Pharmacy, Sonipat, Haryana, INDIA.

Abstract:

Aim: In present investigation, mupirocin coupled copper nanoparticles were synthesized to overwhelm drug resistance in Staphylococcus aureus, responsible for dermal skin infections. Materials and methods: Mupirocin (Anclaima Pvt. Ltd. India), copper sulphate (Thermo Fisher Scientific, India), Tri sodium citrate (Nice chemicals, India) Copper nanoparticles were produced by size reduction method by using Copper Sulphate and Tri sodium citrate. CuNPs were merged into gel base of carbopol which was formed by hot method. Carbapol gel shows no phase separation. Results and Discussion: The particle size of CuNPs was found to be 413.0± 30.2nm. The % EE was found to be 65.2%. On description unilamellar, sphere-shaped vesicles with soft surface were detected under transmission electron microscopy. XRD of CuNPs was found out crystalline in nature. The zeta potential of nanoparticle shows less aggregation of particle with - 15.1 ± 3.69 mV value. The amount of copper content was measured 5.9 microgram/10 mg of nanoparticles. In vitro release study of Cu NPs shows 96.5% release of drug and show effective antibacterial activity against Staphylococcus aureus. Conclusion: Mupirocin copper nanoparticles were produced and show excellent antibacterial activity upon S. aureus.

Keywords: Copper nanoparticle, Mupirocin, Carbopol gel, Antibacterial activity, Chemical reduction method, Copper sulphate.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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