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Published on:October 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(3s):s521-s528
Original Article | doi:10.5530/ijper.54.3s.151

Effect of Atorvastatin on 7,12-Dimethylbenz (α) Anthracene and Testosterone-induced Prostatic Intraepithelial Neoplasia in the Prostate of Wistar Rats: Role of TRPM7


Authors and affiliation (s):

Jianheng Chen1, Zhengchao Shen1, Peng Gu1, Xiaodong Liu1, Jihong Shen1, Bhavin Vyas2, Kunbin Ke1,*

1Department of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, CHINA.

2Department of Pharmacology, Maliba Pharmacy College, Bardoli-Mahuva road, Tarsadi, Surat, Gujarat, INDIA.

Abstract:

Aim/Background: The current study was conducted to examine the influence of atorvastatin in experimentally induced prostatic intraepithelial neoplasia in rats. TRPM7 is a potential therapeutic target for treatment of prostate cancer. Materials and Methods: In this study, we investigated the effects of atorvastatin (25 and 50 mg/kg/BW p.o.) on cell proliferation of prostate induced by a sequential regimen of testosterone plus single administration of 7,12-Dimethylbenz(a) anthracene. Results: Results of present study revealed that the different pattern of prostatic intraepithelial neoplasia with associated High grade PIN in model control group while concurrent treatment with atorvastatin increases the effect by developing a pattern of high grade PIN with dysplasia. Furthermore, atorvastatin treatment produced elevated levels of TRPM7 protein expression with higher Ca/Mg ratio and low ratio of serum testosterone to dihydrotestosterone. Conclusion: The results of the present study indicate that atorvastatin has a promotive role in DMBAtestosterone- induced intraepithelial neoplasia in rats through increasing expression of the TRPM7 channel.

Key words: Atorvastatin, Testosterone, PIN, Ca2+/Mg2+ ratio, TRPM7.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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