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Published on:October 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(3s):s580-s585
Original Article | doi:10.5530/ijper.54.3s.157

Clot Lysis Capacity of Andrographis paniculata and its Pure Compound Andrographolide


Authors and affiliation (s):

Muhammad Torequl Islam1,2,*

1Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM.

2Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM.

Abstract:

Background: Andrographis paniculata and its main components andrographolide (AGL) have been reported for their promising cardio-protective effects in experimental animals. Aim: To investigate clot lysis activity of A. paniculata and AGL. Materials and Methods: The clot lysis activity of the aqueous A. paniculata stem extract (AAP) and AGL was investigated on clotted human blood by using streptokinase (SKE) as a standard drug. Results: Both AAP and AGL showed a concentration-dependent clot lysis activity. AAP showed the highest clot lysis activity at 100 μL (eq. 10% w/v) (54.12 ± 1.22%), while AGL showed at 100 μg/mL (58.62 ± 2.02%). The half maximal effective concentration (EC50) values of AAP and AGL were 87.32 ± 0.37 μL (eq. 8.732% w/v) and 79.74 ± 0.31 μg/mL, respectively. The netagive controls showed negligible clot lysis capacities, while the standard SKE showed 81.54 ± 0.78% clot lysis activity. Conclusion: AAP and its pure component NGL exhibited significant clot lysis activity on human clotted blood and may be good candidates for the treatment of atherothrombosis.

Key words: Andrographis paniculata, Aqueous extract, Andrographolide, Atherothrombosis, Human blood.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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