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Published on:October 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(3s):s593-s600
Original Article | doi:10.5530/ijper.54.3s.159

Phytoformulation of Tagetes patula for Improving Permeability and Prevention of Hyperlipidaemia


Authors and affiliation (s):

Sneha Nawale1,*, Sujit Das2, Priyanka N2, Ganga Raju M3

1Department of Pharmacognosy, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana, INDIA.

2Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana, INDIA.

3Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana, INDIA.

Abstract:

The present study was aimed to formulate phytoformulation of Tagetes patula (MSTP) and its evaluation for antihyperlipidemic activity with triton X-100 and propyl thiouracil induced hyperlipidaemia models. Microsuspension of T. patula extract (50 and 100 mg; MSTP) was developed by precipitation technique. MSTP was assessed for its particle size, pH and drug entrapment efficacy. The results confirmed that microsuspension prepared with Tagetes patula extract (MSPT) showed average particle size 5.92 μm, pH 5.04 and 38 % drug entrapment. MSTP was screened for antihyperlipidemic activity with triton X-100 and propyl thiouracil induced hyperlipidaemia models. MSPT at doses 50 and 100 mg/kg; bd.wt,p.o proved a significant (p<0.01, p<0.05) antihyperlipidaemic potential by reducing levels of TG, TC, VLDL, LDL and shown raised HDL level when results were compared with normal and standard group in propyl thiouracil induced and triton X-100 induced hyperlipidaemia models. MSPT showed prominent antihyperlipidaemic activity as decreased particle size improves the dissolution and bioavailability of poorly soluble secondary metabolites. The results revealed significant antihyperlipidaemic activity for MSPT so can be used for managing hyperlipidaemia and other metabolic disorders.

Key words: Tagetes patula, Micro suspension, Triton X-100, PTU, GC-MS.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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