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Published on:October 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(3s):s512-s520
Original Article | doi:10.5530/ijper.54.3s.150

Fabrication of Triprolidine∙HCl Transdermal Drug Delivery System and Pharmacokinetic Studies


Authors and affiliation (s):

Afzal Haq Asif1, Niranjan Puttaswamy Hodalur2, Nagaraja Sreeharsha3,4,*, Jagadeesh Gurupadayya Hiremath5, Keyur Shileshbhai Mistry6, Bandar E Al-Dhubiab3, Girish Meravanige2, Ranjith Kumar Karnati7, Saleemulla Khan8, Muhammed Mubin9, Aiswarya Thelakkadan Chathoth9

1Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.

2Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.

3Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.

4Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapur Road, Bangalore, INDIA.

5Department of Pharmaceutics, PA College of Pharmacy, Mangalore, INDIA.

6Department of Pharmaceutics, KLE University, Belgaum, Karnataka, INDIA.

7Department of Chemistry, College of Science, King Faisal University, Hofuf, SAUDI ARABIA.

8Department of Pharmacognosy PA College of Pharmacy, Mangalore, INDIA.

9Department of Pharmaceutical Chemistry, PA College of Pharmacy, Mangalore, INDIA.

Abstract:

The purpose was to examine and analyze the matrix system of Triprolidine∙HCl wth the selected polymer ethyl cellulose. We achieved in vitro permeation studies using Keshary Chien diffusion cells across guinea pig skin. Considering the success of permeation enhancers with differing concentrations to enhance the permeation rate. The performed the in vitro dissolution of the developed transdermal patches. The in vivo analysis was carried out on male albino rabbits the drug release was determined by high performance liquid chromatography. The significant high performance liquid chromatography retention time of triprolidine∙HCl was 4.0 min. The limit of detection was 10 ng/mL and quantification limit of was 17 ng/ml. The area under curve was found to be 646.39 ng/ml.hr with the Kel was 0.0682 and Ka was 0.184 hour-1. The peak plasma concentration 24.54 ng/ml were produced in peak time of 8.58 hours with the half life of 10.16 hours.

Key words: Matrix TDDS, Triprolidine∙HCl, Ethyl cellulose, Pharmacokinetics.

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
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Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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