Development and Characterization of Mucoadhesive Buccal Gel Containing Lipid Nanoparticles of Triamcinolone Acetonide

Abstract:

Background: Triamcinolone Acetonide is a synthetic glucocorticosteroid which has been used for its immunosuppressive and anti-inflammatory activity belonging to BCS class IV, yet it is not recommended to be used at higher doses due to its possible adverse effects. Lipid nanoparticle systems are good carriers for poor water soluble drugs, improve permeability and show sustained drug release. Materials and Methods: Triamcinolone Actinide was formulated as Nanostructured Lipid Carriers. High shear homogenization followed by ultra-sonication method was used with Precirol ATO 5 and Isopropyl myristate as lipids. Optimisation was based on their particle size and entrapment efficiency using the design expert software. Conclusion:Formulations F-5 and F-7 were selected as optimised formulations and had drug release patterns that fit Korsmeyer-peppas model kinetics. SEM and TEM studies showed that the Nano structured lipid carriers had size within the nanometre range and morphology resembling type II (amorphous type). The mucoadhesive gel of optimised formulations F-5 and F-7 were prepared as a 1% w/w hydrogel with carbopol 934. These gels showed pseudoplastic fluid nature and good physical properties and also showed a more sustained drug release in comparison to gel incorporated drug suspension. Conclusion: Based on the results obtained it was concluded that Triamcinolone Actinide can be successfully formulated as a gel incorporated with Nanostructured lipid carriers for treatment of buccal diseases.

Key words: Triamcinolone Acetonide, Nanostructured lipid carriers, Mucoadhesive buccal gel, Factorial Design, Response Surface plot.