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Published on:31 Dec 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(4):323-329
Original Article | doi:NILL

Enhancement of Dissolution Rate of Irbesartan by Chitosan based Crystal Engineering Technique


Authors and affiliation (s):

Shete A.S*1, Yadav A.V2 and Murthy M.S3
1Department of Pharmaceutics, Shree Santkrupa College of pharmacy, Ghogoan, Karad-415111, India
2Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara- 415002, India
3Vignan Institute of pharmaceutical sciences, Deshmukhi – 508284 Nalgonda Dist. India

Abstract:

The objectives of present investigations were to enhance dissolution rate of irbesartan by using chitosan and chitosan chlorhydrate and optimize an effective concentrations of both. Cocrystals of irbesartan (IB) were prepared by solvent change technique.Chitosan solution was prepared by soaking chitosan and chitosan chlorhydrate in glacial acetic acid. A weighed amount of drug was dispersed in chitosan solution by stirring. The dispersion was added to sodium citrate solution to precipitate chitosan on drug crystals. The precipitate obtained was filtered through Whatmann No. 1 filter paper using vacuum filtration unit and dried at 450 C for 24 h. The prepared cocrystals were characterized in terms of saturation solubility, drug content, infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), in vitro dissolution studies and stability studies. The considerable improvement in the dissolution rate of drug from optimized co-crystal formulation was attributed to the decreased drug crystallinity, altered surface morphology and reduction in particle size. The 0.2% chitosan and 0.4% chitosan chlorhydrate were found to be optimized concentrations for enhancement of dissolution rate of irbesartan. The technique is scalable and may prove valuable in manufacturing process in future for enhancement of dissolution of poorly water soluble drugs.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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