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Published on:31 Dec 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(4):366-371
Original Article | doi:NILL

Molecular Properties Prediction, Synthesis and Bio-evaluation of Triazines glued Benzothiazole congeners.


Authors and affiliation (s):

Umarani N*, Ilango K, Valentina P and Ishwarya T

Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur-603203, Tamil Nadu, India.

Abstract:

In the current investigation, some newer triazines merged benzothiazole hybrids were subjected to molecular properties prediction, drug-likeness, lipophilicity and solubility parameters determination using Molinspiration, Molsoft and ALOGPS 2.1 softwares. Amongst ten proposed analogues only seven therapeutic candidates were chosen on the basis of Lipinski’s “Rule of Five”. Selected title compounds were synthesized by cyclizing 3-chloroaniline and potassium thiocyanate in presence of bromine yielded the corresponding 2-amino benzothiazole synthon, which on further treatment with different substituted aromatic aldehydes afforded Schiff's bases. The later one condensed with phenyl isothiocyanate gave triazine merged benzothiazole analogues (4a-4j). The structural confirmation of the target compounds were established on the basis of IR, 1HNMR and Mass spectral analysis and subjected to in-vitro anti-inflammatory and anti-oxidant screening. Compound 4c and 4g showed pronounced antioxidant and ant-inflammatory activity respectively. The phenyl ring of triazine bearing –OH and –OCH exhibited good biological activity and their predicted drug-likeness model score also found to be convincing among the series.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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