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Published on:December 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(4):983-990
Original Article | doi:10.5530/ijper.54.4.192

Preparation and Characterization of Directly Compressible Spherical Agglomerates of Etoricoxib


Authors and affiliation (s):

Hagalavadi Nanjappa Shivakumar1, Vanita Somasekhar2,*, Anwesha Roy1

1Department of Pharmaceutics, KLE College of Pharmacy, II Block Rajajinagar, Bangalore, Karnataka, INDIA.

2Department of Pharmaceutical Chemistry, KLE College of Pharmacy, II Block Rajajinagar, Bangalore, Karnataka, INDIA.

Abstract:

Aim: The current work contemplates formulation of spherical agglomerates of Etoricoxib, with a view to improve the flow properties, solubility and dissolution rate. Materials and Methods: Spherical agglomerates of etoricoxib were produced employing quasi emulsion solvent diffusion method using hydrophilic polymers like PVP K30 and PEG 6000. IR spectroscopy and Scanning Electron Microscopy along with physicochemical evaluations were used to characterize the agglomerates. Results: The optical microscopic studies indicated that the agglomerates were spherical in shape and varied in size from 1203.9 ± 126μm to 1297.2 ±164.2μm. The technique was found to enhance the aqueous solubility of the drug from 1.45 μg/ml to 8.26±0.05 μg/ml and the dissolution in 60 min from 39.57% to 82.88%. Etoricoxib tablets prepared using spherical agglomerates with PVP K30 and PEG 6000 displayed dissolution of 82.88% and 76.89% respectively that were considerably higher than conventional etoricoxib tablets. Conclusion: From the dissolution profile and % cumulative release from formulations it was concluded that Spherical Agglomeration technique substantially improves the flow properties, aqueous solubility and rate of dissolution of etoricoxib.

Key words: Etoricoxib, Spherical, Agglomerates, Directly compressible, Flow properties, Rate of dissolution.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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