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Published on:December 2020
Indian Journal of Pharmaceutical Education and Research, 2020; 54(4):1062-1071
Original Article | doi:10.5530/ijper.54.4.201

Xanthine Oxidase and Lipid Peroxidation Inhibition of Taiwan Folkloric Medicine Factors Affecting Rhus semialata var. Roxburghiana Activities against Xanthine Oxidase and Ferrous Iron-induced Lipid Peroxidation on Mice Liver Mitochondria

Authors and affiliation (s):

Po-Wei Tsai1, Pei-Chin Lin2, Ling-Ling Yang3,4, Ai-Ho Liao5,6, Bo-Cheng Wang7,*, Ming-Shun Wu8,9,10,*

1Department of Medical Sciences Industry, College of Health Sciences, Chang Jung Christian University, Tainan, TAIWAN.

2Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei, TAIWAN.

3School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, TAIWAN.

4College of Acupuncture and Oriental Medicine, Houston, Texas, USA.

5Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, TAIWAN.

6Department of Biomedical Engineering, National Defense Medical Center, Taipei, TAIWAN.

7Department of Chemistry, Tamkang University, New Taipei City, TAIWAN.

8Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, TAIWAN.

9School of Medicine, College of Medicine, Taipei Medical University, Taipei, TAIWAN.

10School of Medicine Integrative Therapy Center for Gastroenterologic Cancers, Wan Fang Hospital, Taipei Medical University, Taipei, TAIWAN.


Background: Gout, a disease characterized by recurrent inflammatory for urate deposit from overactive xanthine oxidase, is common among Taiwanese. Rhus semialata var. roxburghiana (RSR) grows wildly in Central Mountain of Taiwan and used by aboriginal Taiwanese as traditional medicine for gout and hepatitis. Methods: In this study, the factors such as variations in RSR extracts in terms of geographical sources, aerial parts and extraction solvents were investigated for antioxidant capabilities, phytochemical analysis and inhibitory effects against xanthine oxidase and lipid peroxidation using ferrous ion as ROS inducer on mice liver mitochondria. Results: The results showed that ML-n-hexane and NS-acetone gave the maximum XO inhibitions (IC50=16.74±0.74 μg/mL) and LPO inhibitions (IC50=8.40±0.35 μg/mL) in the liver mitochondria of mice, respectively. And ML-n-hexane and NS-acetone contained phenolic and flavonoids compounds for its potential target components against XO and LPO in this study. Conclusion: Overall, RSR could lead to a medicinal potential as a suitable candidate for the development of a natural anti-gout and liver damage protective agent that have yet to be conducted.

Key words: Rhus semialata var. Roxburghiana extracts, Geographical source, Xanthine oxidase inhibitor, Free radical scavenging, Liver mitochondria LPO inhibitor.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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