Home | Articles
Published on:March 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(1s):s48-s55
Original Article | doi:10.5530/ijper.55.1s.36

Bioactive Compound Bisacurone in the Turmeric Extract (Turcuron) Prevents Non-alcoholic Fatty Liver Disease by Reduction of Lipogenesis


Authors and affiliation (s):

Kuluvar Gouthamchandra1,*, Heggar Venkataramana Sudeep1, Amritha Raj1, Illuri Ramanaih2, Chandrappa Siddappa2, Kodimule Shyamprasad2

1Department of Biomedicinal Research, R&D Centre for Excellence, Vidya Herbs Pvt. Ltd, Jigani I Phase, Bangalore, Karnataka, INDIA.

2Department of Phytochemistry, R&D Centre for Excellence, Vidya Herbs Pvt. Ltd, Jigani I Phase, Bangalore, Karnataka, INDIA.

Abstract:

Objectives: The current study was carried out to demonstrate potential role of Turcuron, a standardized turmeric extract containing 8% Bisacurone to protect against non-alcoholic fatty liver disease (NAFLD). Methods: HepG2 cell lines exposed to oleic acid (OA) and high-fat diet-induced hepatic steatosis in mice were used as experimental models to explore the hepatoprotective effects of Turcuron. The cytotoxicity was quantitatively assessed by MTT assay. Lipid accumulation and intracellular triglyceride level were evaluated by oil red O staining. Expressions of SREBP-1c and PPAR- γ proteins in the HepG2 cells and in HFD fed mice liver were examined by western blot. Results: Turcuron suppressed fatty acid synthesis and subsided the oleic acid-induced lipid accumulation in HepG2 cells. Moreover, Turcuron also decreased lipid accumulation in the liver of HFDfed mice compared with the control group. The expression of lipogenic genes involved in hepatic lipid metabolism SREBP-1cand PPAR-γ were decreased both in the HepG2 cells and in the liver of Turcuron supplemented mice. These results suggest that Turcuron may actively ameliorate non-alcoholic fatty liver disease. Conclusion: The findings of the present study provide corroborative scientific evidence that Turcuron may actively ameliorate non-alcoholic fatty liver disease.

Key words: NAFLD, Bisacurone, SREBP-1, Oil- O red, HFD.

 




 

Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs