Home | Articles
Published on:1 January, 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(1):38-44
Research Article | doi:NILL

Dissolution rate enhancement of Alprazolam by Solid Dispersion


Authors and affiliation (s):

Roul LK1, *, Manna NK1 , Parhi RN2 , Sahoo S2 and Suresh P2 

1College of Pharmaceutical Sciences, Mahuda, Berhampur, Orissa, India

2GITAM Institute of Pharmacy, GITAM University, Gandhi Nagar Campus, Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India

Abstract:

Solid dispersions were prepared by both solvent evaporation and physical mixing method for poorly water soluble model drug Alprazolam using carriers such as polyethylene glycol-6000 (PEG-6000) and polyvinylpyrrolidone-K30 (PVP-K30) at different proportions (Drug:carriers-1:1, 1:2, 1:4). The solid dispersions were characterized by solubility, drug content uniformity, dissolution rate, similarity factor analysis and stability after 2 months at 300C/75%RH and 400 C/75%RH. More than 80% of Alprazolam was released within 30 minutes of dissolution and the release was more with PVP-K30 when prepared by solvent evaporation method than prepared by physical mixing. The dissolution data's were fitted in Zero 2 order, First order, Higuchi model and Korsmeyer-peppas equation. All the formulations followed Higuchi model (r >0.96) and the 'n' values were within 0.5 to 0.95, which indicates anomalous transport. The formulations containing drug and PEG-6000 and PVP-K30 at 1:1 revealed similar dissolution profile with theoretical dissolution. The stability study indicates condition of 300 C/75%RH as suitable for solid dispersion storage. Tablets were prepared from selected solid dispersions and subjected to various quality control tests. Keywords: Solid dispersion, Similarity factor, Alprazolam

 




 

Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the Latest Release of Journal Citation Reports (source: Web of Science Data).

 

Impact Factor® as reported in the 2023 Journal Citation Reports® (Clarivate Analytics, 2023): 0.8

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs