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Published on:1 January, 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(1):45-51
Research Article | doi:Nill

Fabrication and In vitro Evaluation of High density Gastro retentive Microspheres of Famotidine with Synthetic and Natural Polymers


Authors and affiliation (s):

Hindustan Abdul Ahad*,1 ,Sreeramulu J2 ,Narasimha Reddy D3 ,Guru Prakash P1 and Ramyasree P1 

1Department of Pharmaceutics, College of pharmacy, Sri Krishnadevaraya University, Anantapur- 515003, Andhra Pradesh, India

2 Department of Chemistry, Analytical lab, Sri Krishnadevaraya University, Anantapur- 515003, Andhra Pradesh, India

3 Department of Pharmaceutics, Vivekananda College of Pharmacy, Bangalore, Karnataka India

Abstract:

The main aim of the present work was to fabricate and evaluate gastro retentive high density microspheres with both synthetic and natural polymers for the sustained release of Famotidine to treat gastric ulcers. The microspheres were prepared by the coacervation phase separation technique. Famotidine was checked for its compatibility with polymers used by Fourier Transform Infrared spectroscopy (FTIR). The surface morphology was studied by scanning electron microscopic (SEM) studies. The percentage of yield, surface associated drug content, drug entrapment efficiency and in vitro dissolution studies were performed and the dissolution data was treated with mathematical kinetic models. Accelerated stability studies were also carried out to the optimized formulation (F-6). The FTIR spectrum of pure drug and drug-polymer blend showed the stable character of Famotidine in the micro capsules. The microspheres were found to be spherical. The microspheres had good entrapment efficiency and percentage yield. The release of drug from the microspheres extended up to 12 h. The release kinetics data and characterization studies indicate that drug release from microspheres was diffusion sustained and that the microspheres were stable. The study revealed that Gellan gum and Karaya gum in combinations with Povidone found to be effective combination for microspheres and the gastric retention was aided with Titanium dioxide.

Keywords: Famotidine, Microspheres, Gellan gum, Karaya gum, Titanium dioxide.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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