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Published on:1 January, 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(1):17-22
Research Article | doi:NILL

Hepatoprotective Activity of Dregea volubilis Fruit against Paracetamol-Induced Liver Damage in Rats


Authors and affiliation (s):

Pallab K Haldar*,1 , Moulisha Biswas2 , Sanjib Bhattacharya3 , Tarun K Karan1 and Ashoke K Ghosh4 1Department of Pharmaceutical Technology Jadavpur University, Kolkata, West Bengal, India.

2Bengal Institute of Pharmaceutical Sciences, Kalyani, Nadia, West Bengal, India.

 3Bengal School of Technology, Sugandha, Hooghly, West Bengal, India

4 College of Pharmacy, IFTM, Moradabad, Uttar Pradesh, India

Abstract:

In the present study, the petroleum ether extract of Dregea volubilis (PEDV) was evaluated for its protective effect on paracetamol-induced liver damage in Wistar rats. Serum biochemical parameters viz. serum glutamine oxaloacetate transaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), total protein, bilirubin, cholesterol, triglyceroides; and liver biochemical parameters such as lipid peroxidation, reduced glutathione (GSH) content and catalase (CAT) activity were estimated. Overall biochemical observations indicated that PEDV exerted remarkable hepatoprotective efficacy against paracetamol-induced hepatic damage in rats that is may be due to its augmenting endogenous antioxidant mechanisms.

Keywords: Dregea volubilis, Hepatoprotective, lipid peroxidation, glutathione, silymarin

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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