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Published on:June 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(2s):s396-s404
Original Article | doi:10.5530/ijper.55.2s.111

Datura stramonium Leaves Mucilage Aided Buccoadhesive Films of Aceclofenac using 32 Factorial Design with Design-Expert Software

Authors and affiliation (s):

Hindustan Abdul Ahad*, Haranath Chinthaginjala, Manchikanti Sai Priyanka, Dasari Rahul Raghav, Madana Gowthami, Varam Naga Jyothi

Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Ananthapuramu, Andhra Pradesh, INDIA.


Aim and Objectives: The main motto of this work was to search the additive effect of Datura stramonium leaves mucilage in the making of buccoadhesive film by taking Aceclofenac as a model drug. Materials and Methods: Nine formulations of buccal films were made using Carbopol 934 P and varying proportions of Ethyl Cellulose and D. stramonium leaves mucilage. The films were judged for compatibility studies and physical constraints including Aceclofenac content and discharge. Results: Among the films F-9 containing 1:1 of Aceclofenac and ethyl cellulose; and 1:0.5 ratios of Aceclofenac: D. stramonium leaves mucilage was found to have good Mucoadhesion time (10.5±0.1h) and Bioadhesive strength (5.5±0.2g). The formulation F2 showed the highest % release i.e., 92.85% up to 8 h. Conclusion: The study resolved that buccoadhesive drug delivery system for Aceclofenac with ethyl cellulose aided with D. stramonium leaves mucilage meets the ideal requirement for buccal devices is an efficient approach to surpass the hepatic first-pass metabolism and increase bioavailability.

Key words: Aceclofenac, Mucilage, Factorial design, Buccal Film, Bio adhesive strength.



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Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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