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Published on:June 2021
Indian Journal of Pharmaceutical Education and Research, 2021; 55(2s):s468-s478
Original Article | doi:10.5530/ijper.55.2s.118

Embelin and Levodopa Combination Therapy Mitigates Parkinson's Disease Complications in Mice


Authors and affiliation (s):

Anand Koppal1, Senthilkumar Sivanesan2,*, Vagdevi Hangarakatte Ramachandra1, Ethirajan Sukumar2,3, Rajagopalan Vijayaraghavan2

1Department of Pharmacology, Subbaiah Institute of Medical Sciences and Research Centre, Shivamogga, Karnataka, INDIA.

2Department of Research and Development, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, INDIA.

3Division of Ethnopharmacology and Phytochemistry, Entomology Research Institute, Loyola College, Chennai, Tamil Nadu, INDIA.

Abstract:

Purpose: The present work evaluated the neuroprotective potential of embelin either alone and in combination with Levodopa in rotenone induced PD (Parkinson’s disease) model mice. Methods: Swiss albino male adult mice were randomly divided into 7 groups. Group-1 (Control) received 2mL/kg olive oil by oral route (p.o.), Groups from 2 to 7 were induced with 2.5mg/kg rotenone by intraperitoneal route (i.p.), levodopa was administered to Group-3. Group-4 and Group-5 were given 20mg/kg and 40mg/ kg embelin p.o. Group 6 and 7 were given embelin p.o. at dose of 20 mg and 40 mg/ kg respectively and also 7.5 mg/kg Levodopa p.o. At the end of the experiment (22nd day), blood was withdrawn by retro-orbital puncture to estimate various biochemical parameters and organs such as liver and brain, were dissected for histopathological and histochemical studies. Results: Drug treatment with a combination of embelin (40 mg/ kg) and levodopa (7.5 mg/kg) to PD mice showed better neuroprotective activity than the remaining drug treatment groups based on the results from biochemical, histopathology and α-synuclein protein immunohistochemistry. Conclusion: The current in-vivo research showed that mice treated with embelin at a dose of 40 mg/kg b.w. along with reduced levodopa (7.5 mg/kg) standard therapy was effective to ameliorate rotenone induced PD complications.

Key words: Parkinson’s disease, Swiss albino mice, Rotenone, Embelin, Levodopa.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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