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Published on:1 January, 2012
Indian Journal of Pharmaceutical Education and Research, 2012; 46(1):66-69
Research Article | doi:Nill

Synthesis and Antibacterial Activity of Some 2-(Benzo[d]thiazol-2-ylamino)-5- (arylidene)thiazol-4(5H)-ones


Authors and affiliation (s):

Akbar Mobinikhaledi1 , Somayeh Faghihi1 , Mohammad Hussein Abnusi2 and Seyyed Mehdi Shariatzadeh3
1Department of Chemistry, Faculty of Science, Arak University, Arak 38156-8-8349, Iran
2Department of Biology, Faculty of Science, Arak University, Arak 38156-8-8349, Iran
3Science and Research Branch of Islamic Azad University, Tehran-Iran

Abstract:

Treatment of 2-aminobenzothiazole (1) with chloroacetyl chloride in dry benzene gave N-(benzo[d]thiazol-2-yl)-2-chloroacetamide (3), which under reaction with potassium thiocyanate in refluxing acetone afforded 2-(benzo[d]thiazol-2-ylamino)thiaazol-4(5H)-one (4). 2- Benzothiazolylimino-5-(arylidene)thiazol-4(5H)-one derivatives (5a-m) were synthesized by reaction of (4) with appropriate aromatic aldehydes and assayed their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Streptococcus group D, E. coli, Proteus vulgaris and Klebsiella pneumoniae strains. The antibacterial activity of these compounds revealed that the Bacillus subtilis was the most sensitive strain to 5a, 5c, 5d, 5g, and 5m compared to other investigated bacterial strains.

Keywords: Benzothiazole, Thiazole, Benzylidene, Antibacterial

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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