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Published on:12-2014
Indian Journal of Pharmaceutical Education and Research, 2014; 48(Suppl):18-26
Pharmaceutical Research | doi:10.5530/ijper.48.4s.3

Formulation and Evaluation of Losartan Potassium Osmotic Controlled Matrix Tablets


Authors and affiliation (s):

Vidyadhara S*, Sasidhar RLC, Uma Maheswar V, Sundeep M and Showri babu Ch

Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandarmoulipuram , Chowdavaram , Guntur-522019 , A.P.

Abstract:

Osmotically controlled oral drug delivery systems utilize osmotic pressure as energy source for the controlled delivery of drugs, independent of pH and hydrodynamic conditions of gastro intestinal tract (GIT). The present study was aimed to develop osmotic controlled extended release formulations of Losartan potassium an angiotensin II receptor antagonist with anti-hypertensive activity. Losartan potassium matrix tablets were prepared by direct compression process using HPMC K 15M as polymeric material and mannitol as osmogen at varied concentrations. The matrix tablets were further coated with different compositions of ethylcellulose7cps and PEG-4000 by pan coating method. Physical parameters such as weight uniformity, drug content, hardness and friability were evaluated for uncoated tablets and were found to be within I.P limits. The coating thickness and percentage of coating applied for various tablets were also evaluated. The optimized coated tablets were further subjected to micro drilling on the upper face to get 0.5μm orifice diameter. All the tablets were further subjected to dissolution studies by using USP apparatus II with distilled water as medium. These studies indicated that all the tablets were found to release the drug up to 12 hours, while coated tablets with orifice found to release the drug at zero order rate, which was in good agreement with peppas n values >0.9.

Key words: Losartan potassium, osmotic pressure, micro drilling, controlled release.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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