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Published on:March 2023
Indian Journal of Pharmaceutical Education and Research, 2023; 57(2):511-518
Original Article | doi:10.5530/ijper.57.2.62

New Data for Endemic Phlomis cypria Post from North Cyprus: Biological Activities and LC MS/MS Analysis

Authors and affiliation (s):

İmge Kunter1, Mohammed Tamim Tarabishi1, Niloufar Zabib1, Tuğba Erçetin1, Mehmet İlktaç1, Fatih Göger2,3, Müberra Koşar1,*

1Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, North Cyprus via Mersin, TURKEY.

2Faculty of Pharmacy, Department of Pharmacognosy, Tepebaşı, Eskişehir, TURKEY.

3Department of Pharmacy, Program in Pharmacy Services, Yunus Emre Vocational School, Anadolu University, Tepebaşı, Eskişehir, TURKEY.


Background: The genus Phlomis includes up to 100 species which are distributed throughout Eurasia. Of these species, Phlomis cypria Post (Lamiaceae) is an endemic plant from North Cyprus. P. cypria is commonly used in North Cyprus as medicinal herbal tea for the winter cold and flu. Phlomis species have antioxidant, antimicrobial and anticancer effects. Materials and Methods: In this study, herbal part of P. cypria from North Cyprus was sequentially extracted using hexane, dichloromethane and 70% aqueous methanol and using maceration at room temperature. All extracts were investigated for antiradical (DPPH and ABTS+●), anticholinesterase, antibacterial and the cytotoxic activities and additionally, chemical compositions of the extracts were evaluated by LC MS/MS method. Results: Aqueous methanol extract showed antiradical activities (IC50 0.29 mg/mL in DPPH; TEAC 1.22, 1.36 in ABTS+●) and cytotoxic activities (IC50 1264 μg/mL on SK-HEP 1 cells). Dichloromethane extract only showed activity in anticholinesterase assay (inhibitions were 37.68% for AChE; 21.73% for BChE). Forsytoside B was found as the main phenolic compound in the active extract with caffeic acid bound to other compounds. Conclusion: According to the results, P. cypria could be a potential candidate as cytotoxic and cholineasterase inhibitor agent.

Keywords: Phlomis cypria, Lamiaceae, Antioxidant, Cytotoxicity, Antibacterial, Anticholinesterase.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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