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Published on:12-2014
Indian Journal of Pharmaceutical Education and Research, 2014; 48(Suppl):27-33
Pharmaceutical Research | doi:10.5530/ijper.48.4s.4

A New Kinetic Approach. Stability of Cefquinome Sulfate under Variable pH and Temperature


Authors and affiliation (s):

Mengjiao Liu, Qiang Fu, Hualin Fu*, Gang Shu, Wei Zhang, Fengying Deng, Jun Hu 

Department of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, Ya,an, Sichuan, 625014,China

Abstract:

Object: This study was evaluation of Cefquinome Sulfate (CS) long-term stability under different conditions of pH and temperature, so as to suggest the best conditions to perform its clinical application. Method: The CS stability was investigated at different values of pH (2.0-9.0) and temperature (4-370C). Kinetic parameters of CS degradation in alkaline environment were calculated adopting a new model that took into consideration the equilibrium between the active and a reversibly inactivated form of CS after long-time degradation. Result: All temperatures show increased CS instability, and this effect decreased in following sequence: 370C>250C>150C>40C, which describe typical Arrhenius behaviors with good correlation for Kd(R2= 0.941). Conclusion: The alkali-catalyzed degradation of CS was faster and stronger than the acidic one. The best conditions were met at a pH6.8 and 40C.

Key words: CS, Kinetic parameters, stability, Arrhenius.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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