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Published on:21st April 2014
Indian Journal of Pharmaceutical Education and Research, 2014; 48(2):35-40
Pharmaceutical Education | doi:10.5530/ijper.48.2.5

Promoieties Used In Prodrug Design: A Review


Authors and affiliation (s):

Dhokchawle B. V.*, Gawad J. B., Kamble M. D., Tauro S. J. and Bhandari A. B.1

1Department of Pharmaceutical Chemistry, St John Institute of Pharmacy and Research, Vevoor, Manor Road, Palghar (E), Dist-Thane-401404, Maharashtra

1Dean, Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur-342001, Rajasthan

Abstract:

Despite the success of various prodrugs, surprisingly no other reviews except a review on amino acids as promoieties, which elaborates about amino acids as prodrugs have been published to date. Therefore, we hope that this timely review using both marketed and investigational prodrugs as examples will be of interest for scientists working in the area of drug discovery and development as well as those working in the clinic. In the present commentary we have tried to summarize the different types of promoieties available for prodrug design. The examples of prodrugs using several promoeity are discussed with their advantages and future prospects. The properties and selection of promoieties for the prodrug design is a very crucial parameter in successful prodrug design.

Key words: Promoeity, prodrug, mutual prodrug, amino acid.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs