Home | Articles
Published on:12-2014
Indian Journal of Pharmaceutical Education and Research, 2014; 48(Suppl):1-6
Pharmaceutical Research | doi:10.5530/ijper.48.4s.1

Screening of Mandarin Oil on Indomethcin Induced Inflammatory Bowel Disease in Wistar Rats


Authors and affiliation (s):

N R Patil, V P Rasal, R H Malabade*

Department of Pharmacology, KLEU’s College of Pharmacy, Belgaum

Abstract:

Objective: The present study investigates the protective effect of Mandarin Oil against Indomethacin (INDO) induced Inflammatory Bowel Disease (IBD) in male Wistar rats. Material and Method: IBD was induced by administration of indomethacin solution (7.5 mg/kg b.w., s.c) for 2 days. The study compromises of 5 groups (n=6), normal saline treated, disease induced, Mandarin Oil-I (200 mg/kg), Mandarin Oil-II (400 mg/kg) and Sulfasalazine (standard drug, 500 mg/kg b.w, p.o) treated group. After treatment period animals were sacrificed by cervical dislocation and dissected. Ileum was isolated for macroscopic, microscopic and biochemical studies. Results: Pre-treatment with Mandarin oil shows decrease in macroscopic score for inflammation as compared to indomethacin treated group. Histopathological examination of Mandarin oil treated group revealed less damage compared to indomethacin treated group. Conclusion: Mandarin oil have shown to be effective in indomethacininduced enterocolitis in rats, which has protected the animals against experimentally induced disease because of its antioxidant and anti-inflammatory activities.

Key words: mandarin oil, inflammatory bowel disease, indomethacin, sulfasalazine and anti-oxidant

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.
CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
1 + 18 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.




 

User login

CAPTCHA
This question is for testing whether you are a human visitor and to prevent automated spam submissions.
4 + 8 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs