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Published on:12-2014
Indian Journal of Pharmaceutical Education and Research, 2014; 49(2):146-151
Pharmaceutical Research | doi:10.5530/ijper.49.2.11

Effect of compounds isolated from Filicium decipiens and Ventilago madraspatana against diabetic nephropathy in streptozotocin induced diabetic rats


Authors and affiliation (s):

C. Sasikala*,1, Yajaman Sudhakar2

1Research scholar, Department of Pharmacy, JNTUK, Kakinada, Andhrapradesh- 533003

2Government Polytechnic for Women, Kadapa- 516 002, Andhra Pradesh,

Abstract:

Context: Diabetes mellitus is a group of syndromes characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins and an increased risk of complications from vascular diseases. Filicum decipiens Wight & Arn., (Sapindaceae) and Ventilago madraspatana Gaertn., (Rhamnaceae) are traditionally used for diabetic and other different folk medical uses. Objective: The present study compares the antihperglycemic activity exerted by methanolic extracts of Filicum decipiens (400 mg/kg), Ventilago madraspatana (400 mg/kg), rutin (100 mg/kg), quercetin (50 mg/kg) and combined treatment of rutin with quercetin (100 mg/kg+ (50 mg/kg) on diabetic rats. Material and methods: Methanolic extracts of Filicum decipiens and Ventilago madraspatana leaves were prepared and isolated by soxhlet and solubilization method. Rats were made diabetic by a single dose of streptozotocin (45 mg/kg i.p.). The animals with fasting blood glucose level more than 250 mg/dL were given methanolic leaves extract of Filicum decipiens (400 mg/kg), Ventilago madraspatana (400 mg/kg), quercetin (50 mg/kg), rutin (100 mg/kg) and rutin with quercetin (100 mg/kg + 50 mg/kg) were administered for 45 days and screened for antidiabetic activity. Results and discussion: After 45 days we observed that supplementation with combined dose of rutin and quercetin significantly (p< 0.05) decreased glycosylated hemoglobin (HbA1C) (6.01 mg/g ) and increased the levels of plasma insulin 11.98 μU/mL, hemoglobin 12.12 g/dL, urea 42.16 mg/dL, creatinine 1.41 mg/dL, plasma sodium141.00 mEq/L and urinary potassium 5.11 mEq/L and decrease the activities of enzymatic antioxidant upon STZ treatment and also significantly (p< 0.05) reversed the altered levels and activities of above mentioned diabetic, renal and antioxidant markers in experimental rats as compared to their individual supplementation. Conclusion: Summed effect of quercetin with rutin seems to have a promising value for the development of a potent phytomedicine for diabetic nephropathy.

Key words: Filicum decipiens, Ventilago madraspatana, antioxidant and renal markers.

 




 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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