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Published on:27th Dec, 2014
Indian Journal of Pharmaceutical Education and Research, 2015; 49(1):58-65
Pharmaceutical Research | doi:10.5530/ijper.49.1.8

Studies on Phytochemicals, Antioxidant, Free Radical Scavenging and Lipid Peroxidation Inhibitory effects of Trachyspermum ammi seeds


Authors and affiliation (s):

Vivek K. Bajpai1,*, Pooja Agrawal2
1Department of Applied Microbiology and Biotechnology, Yeungnam University, Gyeongsan, Gyeongbook 712-749, Republic of Korea
2Madhya Pradesh Council of Science & Technology, Vigyan Bhawan, Bhopal 462-003 MP, India

Abstract:

Objective: Reactive oxygen species and free radicals generate oxidative stress in the living cells associated with number of chronic diseases. Current research is directed towards finding naturally occurring antioxidants of plant origin. Hence, this study was aimed to determine phytochemical analysis, antioxidant and free radical scavenging potential of ethanolic seed extract of Trachyspermum ammi (ESETA). Methods: A preliminary phytochemical screening was carried out for the analysis of important phytochemicals present in ESETA. Antioxidant potential of ESETA was evaluated by various scavenging models including DPPH, nitric oxide, superoxide, and hydroxyl radical as well as its lipid peroxidation ability in bovine brain extract. Results: The phytochemical analysis of ESETA revealed the presence of various phytoconstituents including alkaloids, glycosides, terpenoids, saponins, phenols and steroids. The ESETA showed the antioxidant capacity as the inhibition of DPPH radical by 73.41%. Also the ESETA had potent inhibitory effect on scavenging nitric oxide, superoxide, and hydroxyl radicals by 67.33%, 63.22% and 62.48% respectively. Moreover, the ESETA displayed concentration-dependent reducing power ability and remarkable ferric ion-induced lipid peroxidation inhibitory effect (69.22%) in bovine brain extract. Conclusion: These findings confirm the pharmacological efficacy of T. ammi as a potential source of natural antioxidant.

Key words: Trachyspermum ammi, Phytochemicals, Reactive oxygen species, Free radicals, Antioxidant activity.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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