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Published on:27th Dec, 2014
Indian Journal of Pharmaceutical Education and Research, 2015; 49(2):121-125
Pharmaceutical Research | doi:10.5530/ijper.49.2.7

Evaluation of the analgesic effect of Umbellipreninand Umbelliprenin-morphine co-administration on the acute, chronic and neuropathic pain

Authors and affiliation (s):

Mahmoud Hashemzaei1, Mohammad Amin SadeghiBonjar1 , Kaveh Tabrizian1,2, Mehrdad Iranshahi3, Milad Iranshahy3, Ramin Rezaee4

1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran

2Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran

3Department of pharmacognosy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

4Department of Molecular Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran


Background and purpose: Neuropathic pain (NP) is a complex and chronic pain which is accompanied by nerve injury. Umbelliprenin (UMB) is a naturally occurring prenylatedcoumarin with anticancer, antioxidant, anti-inflammatory, antibacterial and antileishmanial activities. This study aimedto investigate the antinociceptive effects of UMB on acute, chronic and neuropathic pain and its combination therapy with morphine on the neuropathic pain. Methods: Albino mice weighing 20-25g were randomly divided into 13 groups (n=7),subjected to hot plate with groups including morphine 1mg+UMB (0.01μM/kg), morphine (1mg/kg, i.p.), UMB (0.01mM/kg), Imipramin 40 mg/kg and NS (normal saline) (0.9%) as vehicle), formalin test with groups including (NS, Imipramine (40mg/kg, i.p.), morphine (9mg/kg, i.p.) and UMB (0.01μM/kg)) and morphine tests with groups including (NS (0.9%), imipramine (40 mg/kg, i.p.), morphine (1mg/kg, i.p.)+UMB (0.01mM/kg) and morphine (1mg/kg, i.p.).The acute and neuropathic pain were evaluated using hot-plate and formalin and morphine tests. Results: Administration of UMB single dose (0.01mM) reduced NP significantly (p<0.05) compared tothe negative control and didn’t change acute pain against Diclofenac. Antinociceptive effects of UMB were comparable to Imipramine as a standard positive control. UMB potentiated morphine 1 mg/kg response onNP. Conclusions: This research indicates that UMB alone reduces NP and its combination with morphine potentiates morphine effects. Therefore, UMB-morphine co-administrationis proposed to be used instead of conventional treatment.

Key words: Umbelliprenin, Neuropathic Pain, Morphine, Sciatic Nerve Ligation.



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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.


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