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Published on:21st April 2014
Indian Journal of Pharmaceutical Education and Research, 2014; 48(2):87-91
Pharmaceutical Education | doi:10.5530/ijper.48.2.12

Spectrophotometric Method For Simultaneous Estimation of Montelukast Sodium and Ebastine in Bulk and Their Combined Tablet Dosage Form


Authors and affiliation (s):

Nikita N. Patel1*, Nikesh S. Rana1, Rajesh K. S1, Parag R.Patel1, Ujjaval Limbachiya1 and T. Y. Pasha2

1Parul Institute of Pharmacy, Waghodia, Limda, Gujarat, India

2Parul Institute of Pharmacy and Research, Waghodia, Limda, Gujarat, India

Abstract:

A simple spectrophotometric method has been developed for simultaneous estimation of Montelukast Sodium and Ebastine from tablet dosage form. Absorbance correction method in which absorbance is measured at two wavelengths, 345 nm at which Ebastine has no absorbance and 253 nm at which both the drugs have considerable absorbance. This method was found linear between the range of 5-25 μg/ml for Montelukast Sodium and Ebastine. The accuracy and precision were determined and found to comply with ICH guidelines. This method showed good reproducibility and recovery with % RSD in the desired range. The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of Montelukast Sodium and Ebastine in their combined tablet dosage form.

Key words: Montelukast Sodium, Ebastine, Absorbance correction method.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs