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Published on:27th Dec, 2014
Indian Journal of Pharmaceutical Education and Research, 2015; 49(1):66-70
Pharmaceutical Research | doi:10.5530/ijper.49.1.9

Screening of Antianxiety Activity of Abies pindrow Royle Aerial Parts


Authors and affiliation (s):

Kumar D and Kumar Suresh*

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala-147 002, Punjab, India

Abstract:

Abies pindrow Royle (Himalayan Silver Fir; Pinaceae) has been traditionally used for the treatment for anxiety but the plant has not been systematically investigated to validate its traditional claims. Thus, it was planned to investigate antianxiety activity of various extracts and fractions of A. pindrow aerial parts using elevated plus maze model (EPM). Properly identified A. pindrow aerial parts were successively and exhaustively extracted using solvents in increasing order of polarity viz., n-hexane, chloroform, methanol and water. All crude extracts were subjected to antianxiety activity at the doses of 100, 200 or 400 mg/kg, p.o. in mice. Efficacy of A. pindrow was statistically compared with the standard anxiolytic drug, diazepam (2 mg/kg, i.p.). Amongst various extracts, chloroform and methanol extract exhibited significant antianxiety activity with respect to control, and statistically equivalent to the standard drug at the dose of 200 and 400 mg/kg, respectively. The bioactive methanol extract was partitioned successively using solvents in increasing order of polarity viz., n-hexane, ethyl acetate and 1-butanol. All fractions were also subjected to antianxiety activity at the doses of 25 or 50 mg/kg, p.o. in mice. Only ethyl acetate fraction (EAF) exhibited significant antianxiety activity equivalent to the standard drug at the dose 50 mg/kg. Present studies scientifically validated traditional claims of A. pindrow for antianxiety activity. Flavonoids of A. pindrow aerial parts have been suggested to play role in treating anxiety disorders.

Key words: Abies pindrow, Anxiolytic, Diazepam, Elevated plus maze.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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