Home | Articles
Published on:12th Jan, 2015
Indian Journal of Pharmaceutical Education and Research, 2015; 49(2):152-157
Pharmaceutical Research | doi:10.5530/ijper.49.2.12

Effect of pioglitazone, quercetin and hydroxy citric acid on inflammatory markers in experimentally induced non alcoholic steatohepatitis (NASH).


Authors and affiliation (s):

Surapaneni Krishna Mohan*1, Mallika Jainu2 *

1Department of Biochemistry, Saveetha Medical College and Hospital, Faculty of Medicine, Saveetha University, Saveetha Nagar, Thandalam, Chennai – 602 105, Tamilnadu, India.

2Department of Biomedical Engineering, SSN Engineering College, OMR, Klavakkam, Chennai – 603 110, Tamilnadu, India.

Abstract:

Background: Non Alcoholic Fatty Liver Disease (NAFLD) spectrum comprises of diseases ranging from simple steatosis to steatohepatitis. Non-Alcoholic Steatohepatitis (NASH), an asymptomatic disease, characterized by the fatty infiltration with inflammation is a key component of NAFLD spectrum that may proceed to the liver cirrhosis, the end stage liver disease, if not diagnosed and treated properly. Inflammatory mediators have been investigated as potential diagnostic tools to understand the pathogenesis of NASH. In this study, the comparative effect of pioglitazone, quercetin and hydroxy citric acid on the levels of inflammatory markers in experimentally induced NASH has been studied. Methods: The experimental protocol consists of 48 Male Wister rats, which were divided into 8 groups. The levels of tumor necrosis factor-α (TNF-α) and myeloperoxidase (MPO) were estimated in experimental NASH. Results: A significant increase in the levels of inflammatory markers such as tumor necrosis factor-α (TNF-α) and myeloperoxidase (MPO) was noticed in experimental NASH rats as compared to control group. On treatment with pioglitazone and quercetin, they showed significant decrease in the levels of TNF-α and MPO. Whereas, on treatment with hydroxy citric acid, no significant effect on the levels of inflammatory markers viz. TNF-α and MPO were observed. Conclusion: By virtue of our findings, it could be inferred that Quercetin and pioglitazone offers protection against NASH by ameliorating the inflammation (hepatitis), a principle and key feature of NASH, whereas hydroxy citric acid offers very little protection against NASH.

Key words: Pioglitazone, Quercetin, Hydroxy citric acid, TNF- α, myeloperoxidase, Non- Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH).

 




 

Impact Factor

IJPER - An Official Publication of Association of Pharmaceutical Teachers of India is pleased to announce continued growth in the 2019 Release of Journal Citation Reports (source: 2018 Web of Science Data).

 

Impact Factor® as reported in the 2018 Journal Citation Reports® (Clarivate Analytics, 2019): 0.425

User login

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

DOI HISTORY

IJPER uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2013 are being assigned DOIs for its permanent URLs