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Published on:15th July 2014
Indian Journal of Pharmaceutical Education and Research, 2014; 48(3):80-90
Pharmaceutical Research | doi:10.5530/ijper.48.3.10

Gamascintigraphic in Vivo-in Vitro Evaluation of Floating Matrix Tablet


Authors and affiliation (s):

Swapnila Shinde (Vanshiv) V1*, Joshi H P2 and Dhas S R1

1 Department of Pharmaceutics, S.T.E.S’s Sinhgad Institute of Pharmacy, Narhe, Pune 411 041, India

2 Manager, Dr. Reddy’s Laboratory, Hyderabad 500049, India

Abstract:

The aim of the present work was to develop hydrodynamically balanced system for atenolol, β-blocker as a single unit floating tablet. Atenolol shows pH dependent solubility resulting into a bioavailability of 36%. Thus site specific oral controlled release floating drug delivery system was developed. Formulation includes the use of rate controlling polymer such as Locust Bean gum (LBG) in combination of HPMC K4M and gas generating agent Sodium bicarbonate. Tablet was prepared by direct compression method and evaluated for physico-mechanical properties. The statistical method was utilized to optimize the effect of independent variables namely amount of HPMC K4M, LBG and three dependent responses such as Cumulative drug release, Floating lag time, Floating time. Graphical and mathematical analysis of the results allowed the identification and quantification of the formulation variables influencing the selected responses. To study the gastrointestinal transit of the optimized gastroretentive formulation, the in vivo Gamascintigraphy was carried out in six healthy rabbits, after radio labeling the formulation with 99mTc. The transit profiles demonstrated that the dosage form was retained in the stomach for more than 5 hrs. The study signifies the potential of the developed system for stomach targeted delivery of Atenolol with improved bioavailability.

Key words: Floating tablet, factorial design, Gamascintigraphy, antihypertensive model drug, HPMC, Locust bean gum.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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