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Published on:15th July 2014
Indian Journal of Pharmaceutical Education and Research, 2014; 48(3):34-47
Pharmaceutical Research | doi:10.5530/ijper.48.3.6

Structural Modification of Proteins and Peptides


Authors and affiliation (s):

Anubha Mahajan*, Ashwani Singh Rawat, Nidhi Bhatt and Meenakshi K. Chauhan

Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, Sector-3, M. B. Road, New Delhi, India – 110017

Abstract:

In recent years, there is an extensive growth in the development of various biologicals and large molecules like proteins and peptides. Proteins and peptides are ubiquitous in every cell and thus are vital for various biological functions. Hence, they are replacing the market of existing organic based pharmaceuticals. This review article intends to summarize various structural modifications that are carried out in order to alter basic properties of peptides and proteins so that their solubility, absorption, permeability and various other problems associated with their delivery can be resolved. Thus they can offer significant therapeutic potential.

Key words: Proteins, peptides, Prodrugs, PEGylation, Polysialation, Lipidization, Hydrophobic ion pairing, Cylcodextrins, Nobex technology, Emisphere Technology

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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