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Published on:December, 2015
Indian Journal of Pharmaceutical Education and Research, 2016; 50(1):179-189
Pharmaceutical Research | doi:10.5530/ijper.50.1.22

Screening of Ethanolic Extract of Diospyros malabarica Desr. Bark for Anti-diabetic and Antioxidant Potential


Authors and affiliation (s):

Satish Annayya Kavatagimath1 and Sunil Satyappa Jalalpure2*

1Department of Pharmaceutical Biotechnology, K.L.E. University, College of Pharmacy, Nehru nagar, Belagavi-10, Karnataka, India.

2K.L.E.U College of Pharmacy and Dr. Prabhakar Kore Basic Science Research Center [BSRC], KLE University, Nehru nagar, Belagavi-590010, Karnataka, India.

Abstract:

Objective: Evaluation of ethanolic extract of Diospyrous malabarica Desr. Bark for anti-diabetic and antioxidant potentials. Materials and Methods: Diospyros malabarica Desr. bark ethanol extract was studied for the OGTT study and acute and sub-acute effects on alloxan induced diabetic rats. Blood glucose levels, Serum lipid profiles and histopathological study of pancreas were performed. The Bark extract was also studied for DPPH radical scavenging potential. Results: Ethanolic extract of bark of Diospyros malabarica significantly improved the glucose tolerance test upto 4h., approximately, 17% and 29% reduction in blood glucose level was observed at 2 h and 4 h respectively. Blood glucose lowering potential percentage was 19% at 6 h in acute studyand after 15 days of treatment it was 39% in Sub acute study. The extract also showed better activity in quenching DPPH radical. Conclusion: Ethanolic extract (200 mg /kg) treated diabetic rats showed partial restoration of normal cellular population and size of islet cells.

Key words: Alloxan induced diabetic rats, Antioxidant, Antidiabetic, Diospyros malabarica Desr., Hypoglycemic.

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