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Published on:December, 2015
Indian Journal of Pharmaceutical Education and Research, 2016; 50(1):190-197
Pharmaceutical Research | doi:10.5530/ijper.50.1.23

Synthesis and In vitro Cytotoxicity of a Novel Efficient Cisplatin-loaded poly N-butyl cyanoacrylate


Authors and affiliation (s):

Nahid Haghnazari1,*, Hadi Mohammadi2, Mohammad Javad Mokhtari3, Changiz Karami4, Soheil Ghasemi5

1Department of biology, Faculty of Science, Sanandaj Branch, Islamic Azad University, Sanandaj-Iran.

2Young Researchers and Elite Club, Kermanshah Branch, Islamic Azad University, Kermanshah-Iran.

3Young Researchers and Elite Club, Zarghan Branch, Islamic Azad University, Zarghan-Iran.

4Department of Chemistry, Kermanshah Branch, Islamic Azad University, Kermanshah-Iran.

5Department of Pilot Nano biotechnology, Pasteur Institute of Iran, Tehran-Iran.

Abstract:

Purpose: Typically, drug-loaded polymer colloidal carriers are synthesized by the drug entrapment during anionic emulsion polymerization. The purpose of this study was to trial the ability of Cisplatin-loaded Poly Butyl Cyanoacrylate (PBCA) nanoparticles. Methods: The cytotoxicity of Cisplatin-loaded PBCA nanoparticles was evaluated by MT assay. The Polymeric nanoparticles have been characterized using TEM, SEM, FTIR and DLS. Results: Polymeric nanoparticles with loaded and unloaded drug prepared by this method, have spherical structure with 350 and 230 nm in diameter and their zeta potentials were -3.2 and -10.7 mv respectively. The average amount of drug loaded on the nanoparticles was 70.88 ± 5.51%. MTT assay was carried out to evaluate the cytotoxicity property of the nanoparticles. Inhibition concentration values (IC50) for Cisplatin-loaded Nanoparticles were 20.8 and 18.2 μM for 24 and 48 h respectively. Conclusion: It was shown that cisplatin-loaded nanoparticles strongly increased cytotoxicity in comparison to classic drug in the MCF-7 cell line.

Key words: Cisplatin, Drug delivery, Emulsion polymerization, Encapsulation, Polymeric Nanoparticles.

 

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The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmaceutical Education and Research (IJPER) [ISSN-0019-5464] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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